Kanchana Tomanakan
Division of immunology, Department of Clinical Pathology, Khon Kaen Hospital.
Eposinophilic meningitis caused by Parastrongylus cantonensis, the rat lung worm is the major public health problem in Thailand. Human acquire this parasite by eating raw food containing infective larvae. A specific diagnosis of Parastrongyliasis is difficult to make because identification of parasite materials by biospy or chance finding is rarely possible. The purpose of this study was to develop alternative appeoaches of Parastrongylus cantonensis infection employing crude antigem by dot-biot ELISA. The investigation was cairred out between October 2003 to July 2004 in Khon Kaen which is endemic area. 132 sera from several villagers of this study area were divided into 5 groups. Group 1 consisted of 30 patients with Cryptococcal meningitis, group 2 were 22 cases of Bacterial meningitis, group 3 were 32 cases of eosinophilic meningitis, group 4 were other parasite infection ( 4 from Cysticercosis, 2 from Fascioliasis, 12 from Malaria) and group 5 were 30 negative healthy control. The result demonstrated that 26 cases of eosinophilic meningitis, were positive with Dot-blot ELISA. (81.3%) None of the other groups of sample reacted with this antigen. By the data obtained show that Dot-blot ELISA has potential in diagnosis of Eosinophilic meningitis caused by Parastrongylus cantonensis
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การประชุมวิชาการกระทรวงสาธารณสุขครั้งที่ 13 ประจำปี 2548
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